1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

initialism: MPTP
https://doi.org/10.1351/goldbook.11871
Synthetic substance causing parkinsonism.
Note: Originally a toxic by-product in the illicit manufacture of the synthetic opioid meperidine, thus with neurotoxicity first detected in drug abusers, it is used as a model substance for studying the pathogenesis of parkinsonism.
Source:
PAC, 2015, 87, 841. (IUPAC Glossary of terms used in neurotoxicology (IUPAC Recommendations 2015)) on page 881 [Terms] [Paper]
Citation: '1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.11871 RIS BibTex EndNote
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