Title: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Long Title: IUPAC Gold Book - 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
DOI: 10.1351/goldbook.11871
Status: current

Definition
Synthetic substance causing parkinsonism.

Note
Originally a toxic by-product in the illicit manufacture of the synthetic opioid meperidine, thus with neurotoxicity first detected in drug abusers, it is used as a model substance for studying the pathogenesis of parkinsonism.

Related Terms
- opioid: https://goldbook.iupac.org//terms/view/11975
- parkinsonism: https://goldbook.iupac.org//terms/view/11998

Source
- PAC, 2015, 87, 841. 'IUPAC Glossary of terms used in neurotoxicology (IUPAC Recommendations 2015)' on page 881 (https://doi.org/10.1515/pac-2015-0103)

Other Outputs
- html: https://goldbook.iupac.org/terms/view/11871/html
- json: https://goldbook.iupac.org/terms/view/11871/json
- xml: https://goldbook.iupac.org/terms/view/11871/xml

Citation: Citation: '1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.11871
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Accessed: 2026-07-15T07:15:59+00:00