https://doi.org/10.1351/goldbook.09865
Specifically-designed single-stranded nucleic acid with a defined (known) nucleotide sequence immobilised on a surface.
Notes:
- Capture probes are utilised as a recognition element to test the nucleotide sequence of target deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) in the sample solution by using DNA or RNA hybridization.
- An analogous principle, based on immobilised nucleic acid probes, has been applied in studies of the interactions of nucleic acids with proteins or other targets. See also nucleic acid aptamers.
Examples: Nucleic acids: ssDNA (alternatively, RNA or a synthetic nucleic acid analogue, such as locked nucleic acid (LNA) or peptide nucleic acid (PNA)). Surfaces: microarray, magnetic, or other micro/nanoparticle, a transducer of a biosensor.