peptide nucleic acid

initialism: PNA
https://doi.org/10.1351/goldbook.09714
Synthetic deoxyribonucleic acid (DNA) mimic, which contains 2-aminoethylglycine linkages instead of the negatively charged phosphodiesteric backbone of oligonucleotides.
Note: The PNA probes are particularly convenient for the detection of single-base mismatches (point mutations, SNPs), because the stability of DNA-PNA duplexes is strongly influenced by a single-base mismatch.
Source:
PAC, 2018, 90, 1121. (Terminology of bioanalytical methods (IUPAC Recommendations 2018)) on page 1150 [Terms] [Paper]
Citation: 'peptide nucleic acid' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.09714 RIS BibTex EndNote
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