nuclear Overhauser effect spectroscopy

synonym: nuclear Overhauser enhancement spectroscopy
acronym: NOESY
https://doi.org/10.1351/goldbook.08387
Measurement method of nuclear magnetic resonance spectroscopy based on the nuclear Overhauser effect to observe nuclei that are close to each other in space.
Notes:
  1. NOESY is typically run as a homonuclear \(\ce{^{1}H}\) experiment.
  2. A NOESY spectrum yields through space correlations via dipolar cross-relaxation.
  3. For small molecules, NOE may be observed between protons that are up to \(\pu{0.4 nm}\) apart, while the upper limit for large molecules is about \(\pu{0.5 nm}\).
  4. NOESY also detects chemical and conformational exchange, when it is termed exchange spectroscopy (EXSY).
Source:
PAC, 2021, 93, 647. (Glossary of methods and terms used in analytical spectroscopy (IUPAC Recommendations 2019)) on page 698 [Terms] [Paper]
Citation: 'nuclear Overhauser effect spectroscopy' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.08387 RIS BibTex EndNote
Div. VTextXMLJSON