{"term":{"id":"08387","title":"nuclear Overhauser effect spectroscopy","longtitle":"IUPAC Gold Book - nuclear Overhauser effect spectroscopy","doi":"10.1351\/goldbook.08387","code":"08387","status":"current","acronym":"<em>acronym<\/em>: NOESY","synonym":"<em>synonym<\/em>: nuclear Overhauser enhancement spectroscopy","definitions":[{"id":1,"text":"Measurement method of nuclear magnetic resonance spectroscopy based on the nuclear Overhauser effect to observe nuclei that are close to each other in space.","notes":{"1":"NOESY is typically run as a homonuclear \\(\\ce{^{1}H}\\) experiment.","2":"A NOESY spectrum yields through space correlations via dipolar cross-relaxation.","3":"For small molecules, NOE may be observed between protons that are up to \\(\\pu{0.4 nm}\\) apart, while the upper limit for large molecules is about \\(\\pu{0.5 nm}\\).","4":"NOESY also detects chemical and conformational exchange, when it is termed exchange spectroscopy (EXSY)."},"links":[{"term":"exchange spectroscopy","url":"https:\/\/goldbook.iupac.org\/\/terms\/view\/08340"},{"term":"nuclear Overhauser effect","url":"https:\/\/goldbook.iupac.org\/\/terms\/view\/08385"},{"term":"nuclear magnetic resonance spectroscopy","url":"https:\/\/goldbook.iupac.org\/\/terms\/view\/08218"},{"term":"spectrum","url":"https:\/\/goldbook.iupac.org\/\/terms\/view\/08384"}],"sources":["PAC, 2021, 93, 647. 'Glossary of methods and terms used in analytical spectroscopy (IUPAC Recommendations 2019)' on page 698 (https:\/\/doi.org\/10.1515\/pac-2019-0203)"]}],"altoutputs":{"html":"https:\/\/goldbook.iupac.org\/terms\/view\/08387\/html","xml":"https:\/\/goldbook.iupac.org\/terms\/view\/08387\/xml","plain":"https:\/\/goldbook.iupac.org\/terms\/view\/08387\/plain"},"citation":"Citation: 'nuclear Overhauser effect spectroscopy' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351\/goldbook.08387","license":"The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/) for individual terms.","collection":"If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org .","disclaimer":"The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.","accessed":"2026-05-30T22:34:44+00:00"}}