Title: nuclear Overhauser effect spectroscopy
Long Title: IUPAC Gold Book - nuclear Overhauser effect spectroscopy
DOI: 10.1351/goldbook.08387
Status: current

Definition
Measurement method of nuclear magnetic resonance spectroscopy based on the nuclear Overhauser effect to observe nuclei that are close to each other in space.

Notes
1) NOESY is typically run as a homonuclear \(\ce{^{1}H}\) experiment.
2) A NOESY spectrum yields through space correlations via dipolar cross-relaxation.
3) For small molecules, NOE may be observed between protons that are up to \(\pu{0.4 nm}\) apart, while the upper limit for large molecules is about \(\pu{0.5 nm}\).
4) NOESY also detects chemical and conformational exchange, when it is termed exchange spectroscopy (EXSY).

Related Terms
- exchange spectroscopy: https://goldbook.iupac.org//terms/view/08340
- nuclear Overhauser effect: https://goldbook.iupac.org//terms/view/08385
- nuclear magnetic resonance spectroscopy: https://goldbook.iupac.org//terms/view/08218
- spectrum: https://goldbook.iupac.org//terms/view/08384

Source
- PAC, 2021, 93, 647. 'Glossary of methods and terms used in analytical spectroscopy (IUPAC Recommendations 2019)' on page 698 (https://doi.org/10.1515/pac-2019-0203)

Other Outputs
- html: https://goldbook.iupac.org/terms/view/08387/html
- json: https://goldbook.iupac.org/terms/view/08387/json
- xml: https://goldbook.iupac.org/terms/view/08387/xml

Citation: Citation: 'nuclear Overhauser effect spectroscopy' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.08387
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Accessed: 2026-05-30T22:35:13+00:00