TDP-43 transcription factor

https://doi.org/10.1351/goldbook.12123
Cleavage product (\(\pu{43 kDa}\)) of the transactive response (TAR) DNA binding protein (TARDBP) that targets TAR DNA and transcriptionally represses HIV-1.
Note: Pathological accumulation of the misfolded protein cleavage product has been associated with frontotemporal dementia and amyotrophic lateral sclerosis.
Source:
PAC, 2015, 87, 841. (IUPAC Glossary of terms used in neurotoxicology (IUPAC Recommendations 2015)) on page 910 [Terms] [Paper]
Citation: 'TDP-43 transcription factor' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.12123 RIS BibTex EndNote
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