amyotrophic lateral sclerosis

synonyms: Lou Gehrig’s disease, motor neuron disease
https://doi.org/10.1351/goldbook.11583
Debilitating degenerative disease of the motor neurons characterized by progressive muscle weakness, muscle atrophy and fasciculations, muscle spasticity, difficulty speaking (dysarthria), difficulty swallowing (dysphagia), and difficulty breathing (dyspnea).
Source:
PAC, 2015, 87, 841. (IUPAC Glossary of terms used in neurotoxicology (IUPAC Recommendations 2015)) on page 846 [Terms] [Paper]