testicular feminization

https://doi.org/10.1351/goldbook.11294

Type of male pseudohermaphroditism in which the individual has a male karyotype and testes present within the abdominal cavity, but develops external female genitalia and female secondary sexual characteristics.

Notes:
  1. Testicular feminization is due to an androgen receptormutation, causing the target tissues to be insensitive to the masculinizing effects of androgens.
  2. Clinical presentation is usually as a phenotypic female with primary amenorrhea.
Source:
PAC, 2016, 88, 713. (Glossary of terms used in developmental and reproductive toxicology (IUPAC Recommendations 2016)) on page 812 [Terms] [Paper]
Citation: 'testicular feminization' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.11294 RIS BibTex EndNote
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