{"term":{"id":"11294","title":"testicular feminization","longtitle":"IUPAC Gold Book - testicular feminization","doi":"10.1351\/goldbook.11294","code":"11294","status":"current","definitions":[{"id":1,"text":"Type of male pseudohermaphroditism in which the individual has a male karyotype and testes present within the abdominal cavity, but develops external female genitalia and female secondary sexual characteristics.","notes":{"1":"Testicular feminization is due to an androgen receptormutation, causing the target tissues to be insensitive to the masculinizing effects of androgens.","2":"Clinical presentation is usually as a phenotypic female with primary amenorrhea."},"links":[{"term":"abdominal cavity","url":"https:\/\/goldbook.iupac.org\/\/terms\/view\/10318"},{"term":"amenorrhea","url":"https:\/\/goldbook.iupac.org\/\/terms\/view\/10365"},{"term":"androgen receptor","url":"https:\/\/goldbook.iupac.org\/\/terms\/view\/10386"},{"term":"androgens","url":"https:\/\/goldbook.iupac.org\/\/terms\/view\/10384"},{"term":"genitalia","url":"https:\/\/goldbook.iupac.org\/\/terms\/view\/10755"},{"term":"karyotype","url":"https:\/\/goldbook.iupac.org\/\/terms\/view\/10872"},{"term":"masculinizing","url":"https:\/\/goldbook.iupac.org\/\/terms\/view\/10918"},{"term":"pseudohermaphroditism","url":"https:\/\/goldbook.iupac.org\/\/terms\/view\/11149"},{"term":"secondary sexual characteristics","url":"https:\/\/goldbook.iupac.org\/\/terms\/view\/11198"},{"term":"testes","url":"https:\/\/goldbook.iupac.org\/\/terms\/view\/11295"}],"sources":["PAC, 2016, 88, 713. 'Glossary of terms used in developmental and reproductive toxicology (IUPAC Recommendations 2016)' on page 812 (https:\/\/doi.org\/10.1515\/pac-2015-1202)"]}],"altoutputs":{"html":"https:\/\/goldbook.iupac.org\/terms\/view\/11294\/html","xml":"https:\/\/goldbook.iupac.org\/terms\/view\/11294\/xml","plain":"https:\/\/goldbook.iupac.org\/terms\/view\/11294\/plain"},"citation":"Citation: 'testicular feminization' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351\/goldbook.11294","license":"The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/) for individual terms.","collection":"If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org .","disclaimer":"The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.","accessed":"2026-07-12T16:42:28+00:00"}}