one-generation reprotox study

https://doi.org/10.1351/goldbook.11039

Procedure in which male rodents are dosed with a test substance for at least one spermatogenic cycle, and females for two estrous cycles, and then further exposed during mating, pregnancy, and nursing; adverse effects on reproduction, parturition, lactation and postnatal growth are studied.

Source:
PAC, 2016, 88, 713. (Glossary of terms used in developmental and reproductive toxicology (IUPAC Recommendations 2016)) on page 787 [Terms] [Paper]