https://doi.org/10.1351/goldbook.10864
Apoptotic pathway of cell death initiated from within the cell by signals initiated by mitochondrial damage and (or) DNA damage, a defective cell cycle, detachment from the extracellular matrix, hypoxia, loss of cell survival factors, or other types of severe cell stress; characterized by the activation of caspase 9.
Notes:
- This pathway involves the release of pro-apoptotic proteins from the mitochondria.
- The intrinsic and extrinsic pathways converge with cleavage of procaspase 3 by either caspase 8 (extrinsic pathway) or caspase 9 (intrinsic pathway).