intrinsic pathway

https://doi.org/10.1351/goldbook.10864

Apoptotic pathway of cell death initiated from within the cell by signals initiated by mitochondrial damage and (or) DNA damage, a defective cell cycle, detachment from the extracellular matrix, hypoxia, loss of cell survival factors, or other types of severe cell stress; characterized by the activation of caspase 9.

Notes:
  1. This pathway involves the release of pro-apoptotic proteins from the mitochondria.
  2. The intrinsic and extrinsic pathways converge with cleavage of procaspase 3 by either caspase 8 (extrinsic pathway) or caspase 9 (intrinsic pathway).
Source:
PAC, 2016, 88, 713. (Glossary of terms used in developmental and reproductive toxicology (IUPAC Recommendations 2016)) on page 770 [Terms] [Paper]
Citation: 'intrinsic pathway' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.10864 RIS BibTex EndNote
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