Apoptotic pathway of cell death initiated from within the cell by signals initiated by mitochondrial damage and (or) DNA damage, a defective cell cycle, detachment from the extracellular matrix, hypoxia, loss of cell survival factors, or other types of severe cell stress; characterized by the activation of caspase 9.
Notes: - This pathway involves the release of pro-apoptotic proteins from the mitochondria.
- The intrinsic and extrinsic pathways converge with cleavage of procaspase 3 by either caspase 8 (extrinsic pathway) or caspase 9 (intrinsic pathway).
Source:
PAC, 2016, 88, 713. 'Glossary of terms used in developmental and reproductive toxicology (IUPAC Recommendations 2016)' on page 770 (https://doi.org/10.1515/pac-2015-1202)