https://doi.org/10.1351/goldbook.10702
Apoptotic pathway of cell death initiated upon occupancy of so-called death receptors at the cell surface with their ligands, such as Fas/CD95 and tumor necrosis factor-\(\upalpha\!\), and involving activation of caspase 8.
Note: This pathway converges with the intrinsic pathway at the level of cleavage of procaspase 3 by either caspase 8 (extrinsic pathway) or caspase 9 (intrinsic pathway).