Apoptotic pathway of cell death initiated upon occupancy of so-called death receptors at the cell surface with their ligands, such as Fas/CD95 and tumor necrosis factor-
\(\upalpha\!\), and involving activation of caspase 8.
Note: This pathway converges with the
intrinsic pathway at the level of cleavage of procaspase 3 by either caspase 8 (extrinsic pathway) or caspase 9 (
intrinsic pathway).
Source:
PAC, 2016, 88, 713. 'Glossary of terms used in developmental and reproductive toxicology (IUPAC Recommendations 2016)' on page 753 (https://doi.org/10.1515/pac-2015-1202)