https://doi.org/10.1351/goldbook.09867
Formation of a covalent bridge between two biomacromolecules or between two segments of the same biomacromolecule using reactive substances (e.g. formaldehyde, bifunctional aldehydes such as glutaraldehyde, or cisplatin) or photochemical processes.
Note: Cross-linking is used to study protein oligomerization, as well as protein–protein and nucleic acid–protein interactions