Formation of a covalent bridge between two biomacromolecules or between two segments of the same biomacromolecule using reactive substances (e.g. formaldehyde, bifunctional aldehydes such as glutaraldehyde, or cisplatin) or photochemical processes.
Note: Cross-linking is used to study protein oligomerization, as well as protein–protein and nucleic acid–protein interactions
See: chromatin immunoprecipitation
Source:
PAC, 2018, 90, 1121. 'Terminology of bioanalytical methods (IUPAC Recommendations 2018)' on page 1183 (https://doi.org/10.1515/pac-2016-1120)