proteolysis

https://doi.org/10.1351/goldbook.09776

Protein cleavage to generate proteolytic peptides for bottom-up proteomic analysis, either enzymatic or chemical.

Note: Both enzymatic and chemical proteolysis may be sequence-specific or unspecific. Proteolysis is specific where cleavage appears at a few specific sequence motives (e.g. proteolysis by trypsin), or unspecific, being connected to wide range of sequence motives (e.g. proteolysis by chymotrypsin).
Source:
PAC, 2018, 90, 1121. (Terminology of bioanalytical methods (IUPAC Recommendations 2018)) on page 1162 [Terms] [Paper]
Citation: 'proteolysis' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.09776 RIS BibTex EndNote
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