https://doi.org/10.1351/goldbook.08152
Monoclonal antibody with enzymatic activity.
Notes:
- A catalytic antibody acts by binding its antigen and catalyzing a chemical reaction that converts the antigen into desired products. Despite the existence of natural catalytic antibodies, most of them were specifically designed to catalyze desired chemical reactions.
- Catalytic antibodies are produced through immunization against a transition-state analogue for the reaction of interest. The resulting antibodies bind strongly and specifically the transition-state analogue, so that they become catalysts for the desired reaction.
- The concept of catalytic antibodies and the strategy for obtaining them were advanced by W. P. Jencks. The first catalytic antibodies were finally produced in 1986.