catalytic antibody

synonym: abzyme
https://doi.org/10.1351/goldbook.08152
Monoclonal antibody with enzymatic activity.
Notes:
  1. A catalytic antibody acts by binding its antigen and catalyzing a chemical reaction that converts the antigen into desired products. Despite the existence of natural catalytic antibodies, most of them were specifically designed to catalyze desired chemical reactions.
  2. Catalytic antibodies are produced through immunization against a transition-state analogue for the reaction of interest. The resulting antibodies bind strongly and specifically the transition-state analogue, so that they become catalysts for the desired reaction.
  3. The concept of catalytic antibodies and the strategy for obtaining them were advanced by W. P. Jencks. The first catalytic antibodies were finally produced in 1986.
Source:
PAC, 2022, 94, 353. 'Glossary of terms used in physical organic chemistry (IUPAC Recommendations 2021)' on page 380 (https://doi.org/10.1515/pac-2018-1010)