Monoclonal antibody with enzymatic activity.
Notes: - A catalytic antibody acts by binding its antigen and catalyzing a chemical reaction that converts the antigen into desired products. Despite the existence of natural catalytic antibodies, most of them were specifically designed to catalyze desired chemical reactions.
- Catalytic antibodies are produced through immunization against a transition-state analogue for the reaction of interest. The resulting antibodies bind strongly and specifically the transition-state analogue, so that they become catalysts for the desired reaction.
- The concept of catalytic antibodies and the strategy for obtaining them were advanced by W. P. Jencks. The first catalytic antibodies were finally produced in 1986.
Source:
PAC, 2022, 94, 353. 'Glossary of terms used in physical organic chemistry (IUPAC Recommendations 2021)' on page 380 (https://doi.org/10.1515/pac-2018-1010)