This principle applies to reactions in which there is a lack of synchronization between bond formation or bond rupture and other @P04845@ that affect the stability of products and reactants, such as @R05326@, @S05747@, electrostatic, @H02899@ and @P04711@ effects. The principle states that a product-stabilizing factor whose development lags behind bond changes at the @T06468@, or a reactant-stabilizing factor whose loss is ahead of bond changes at the @T06468@, increases the @I03135@ and decreases the 'intrinsic @O04322@' of a reaction. For a product-stabilizing factor whose development is ahead of bond changes, or reactant factors whose loss lags behind bond changes, the opposite relations hold. The reverse effects are observable for factors that destabilize a reactant or product.