pro-R, pro-S

https://doi.org/10.1351/goldbook.P04889
A @S05981@ group c (as in tetrahedral Xabc2) is described as pro-R if, when it is arbitrarily assigned @C01082@ over the other @S05981@ group c, the configuration of the thus generated @C01057@ centre is assigned the @S05976@ R. The other group c is then described as pro-S. This method for distinguishing between @S05981@ groups can be applied to other kinds of prochiral molecular entities or @P04859@ parts of molecular entities considered on their own.
See:
prochirality centre
Source:
PAC, 1996, 68, 2193. (Basic terminology of stereochemistry (IUPAC Recommendations 1996)) on page 2214 [Terms] [Paper]
Citation: 'pro-R, pro-S' in IUPAC Compendium of Chemical Terminology, 3rd ed. International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. https://doi.org/10.1351/goldbook.P04889 RIS BibTex EndNote
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Last revised: February 24, 2014