method of isotopic perturbation

https://doi.org/10.1351/goldbook.M03880
NMR shift difference measurement of the @I03327@ on a fast (degenerate) equilibrium between two species which are equivalent except for isotopic substitution. This can be used to distinguish a rapidly equilibrating mixture with time-averaged symmetry from a single structure with higher symmetry.
Source:
PAC, 1994, 66, 1077. (Glossary of terms used in physical organic chemistry (IUPAC Recommendations 1994)) on page 1132 [Terms] [Paper]
Citation: 'method of isotopic perturbation' in IUPAC Compendium of Chemical Terminology, 3rd ed. International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. https://doi.org/10.1351/goldbook.M03880 RIS BibTex EndNote
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Last revised: February 24, 2014