clearance

in toxicology
https://doi.org/10.1351/goldbook.CT06860
  1. Volume of blood or plasma or mass of an organ effectively cleared of a substance by @E02038@ (@M03858@ and excretion) divided by time of @E02038@.
    Note:
    Total @CT01101@ is the sum of the clearances of each eliminating organ or tissue for a given substance.
  2. (in pulmonary toxicology) Volume or mass of lung cleared divided by time of @E02038@; used qualitatively to describe removal of any inhaled substance which deposits on the lining surface of the lung.
  3. (in renal toxicology) Quantification of the removal of a substance by the kidneys by the processes of @F02388@ and secretion; @CT01101@ is calculated by relating the rate of renal excretion to the plasma concentration.
See also:
clearance, \(^{\Delta V}/_{\Delta t}\)
Source:
PAC, 2004, 76, 1033. (Glossary of terms used in toxicokinetics (IUPAC Recommendations 2003)) on page 1045 [Terms] [Paper]
Citation: 'clearance' in IUPAC Compendium of Chemical Terminology, 3rd ed. International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. https://doi.org/10.1351/goldbook.CT06860 RIS BibTex EndNote
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Last revised: February 24, 2014