Volume of blood or plasma or mass of an organ effectively cleared of a substance by elimination (metabolism and excretion) divided by time of elimination.
Note: Total @CT01101@ is the sum of the clearances of each eliminating organ or tissue for a given substance.
(in pulmonary toxicology) Volume or mass of lung cleared divided by time of elimination; used qualitatively to describe removal of any inhaled substance which deposits on the lining surface of the lung.
(in renal toxicology) Quantification of the removal of a substance by the kidneys by the processes of filtration and secretion; clearance is calculated by relating the rate of renal excretion to the plasma concentration.
See also: clearance, \(^{\Delta V}/_{\Delta t}\)
Source: PAC, 2004, 76, 1033. 'Glossary of terms used in toxicokinetics (IUPAC Recommendations 2003)' on page 1045 (https://doi.org/10.1351/pac200476051033)