itai-itai disease

https://doi.org/10.1351/goldbook.15838
Illness (renal osteomalacia) observed in the Toyama prefecture of Japan, resulting from the ingestion of cadmium-contaminated rice.
Note: Damage occurred to the renal and skeleto-articular systems, the latter being very painful ("itai" means "ouch" in Japanese and refers to the intense pain caused by the condition).
Source:
PAC, 2007, 79, 1153. (Glossary of terms used in toxicology, 2nd edition (IUPAC Recommendations 2007)) on page 1248 [Terms] [Paper]