{"term":{"id":"15838","title":"itai-itai disease","longtitle":"IUPAC Gold Book - itai-itai disease","doi":"10.1351\/goldbook.15838","code":"15838","status":"current","definitions":[{"id":1,"text":"Illness (renal osteomalacia) observed in the Toyama prefecture of Japan, resulting from the ingestion of cadmium-contaminated rice.","notes":{"1":"Damage occurred to the renal and skeleto-articular systems, the latter being very painful (\"itai\" means \"ouch\" in Japanese and refers to the intense pain caused by the condition)."},"sources":["PAC, 2007, 79, 1153. 'Glossary of terms used in toxicology, 2nd edition (IUPAC Recommendations 2007)' on page 1248 (https:\/\/doi.org\/10.1351\/pac200779071153)"]}],"altoutputs":{"html":"https:\/\/goldbook.iupac.org\/terms\/view\/15838\/html","xml":"https:\/\/goldbook.iupac.org\/terms\/view\/15838\/xml","plain":"https:\/\/goldbook.iupac.org\/terms\/view\/15838\/plain"},"citation":"Citation: 'itai-itai disease' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351\/goldbook.15838","license":"The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/) for individual terms.","collection":"If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org .","disclaimer":"The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.","accessed":"2026-05-30T17:41:39+00:00"}}