irreversible alteration

https://doi.org/10.1351/goldbook.15835
Change from normal structure or function that persists or progresses after cessation of exposure of the organism.
Source:
PAC, 2007, 79, 1153. (Glossary of terms used in toxicology, 2nd edition (IUPAC Recommendations 2007)) on page 1247 [Terms] [Paper]