https://doi.org/10.1351/goldbook.13479
Undifferentiated stem cell, obtained from adult bone marrow or other non-embryonic tissue sources, that possesses the ability to differentiate into a variety of cell types, especially into cells of a closely related family of cells that are expanded in vitro and deposited in master cell banks for "off-the-shelf" use, with potential hematopoiesis-inducing and immunomodulating activities.
Notes:
- Allogeneic multipotent adult progenitor cells (MAPCs) are non-immunogenic due to the lack of major histocompatibility complex (MHC) molecule expression, and so elicit no immune response upon administration.
- In vivo, bone marrow-derived adult stem cells are capable of maturing into a broad range of cell types and may help to restore the immune system by producing multiple therapeutic molecules in response to inflammation and tissue damage.