13479 IUPAC Gold Book - multipotent progenitor cell 10.1351/goldbook.13479 13479 current 1 Undifferentiated stem cell, obtained from adult bone marrow or other non-embryonic tissue sources, that possesses the ability to differentiate into a variety of cell types, especially into cells of a closely related family of cells that are expanded in vitro and deposited in master cell banks for "off-the-shelf" use, with potential hematopoiesis-inducing and immunomodulating activities. Allogeneic multipotent adult progenitor cells (MAPCs) are non-immunogenic due to the lack of major histocompatibility complex (MHC) molecule expression, and so elicit no immune response upon administration. In vivo, bone marrow-derived adult stem cells are capable of maturing into a broad range of cell types and may help to restore the immune system by producing multiple therapeutic molecules in response to inflammation and tissue damage. Allogeneic https://goldbook.iupac.org//terms/view/12862 bone marrow https://goldbook.iupac.org//terms/view/12959 immune system https://goldbook.iupac.org//terms/view/13271 major histocompatibility complex (MHC) molecule https://goldbook.iupac.org//terms/view/13434 PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1216 (https://doi.org/10.1351/PAC-REC-11-06-03) https://goldbook.iupac.org/terms/view/13479/html https://goldbook.iupac.org/terms/view/13479/json https://goldbook.iupac.org/terms/view/13479/plain Citation: 'multipotent progenitor cell' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13479 The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) for individual terms. If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org . The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using. 2026-08-03T20:38:00+00:00