liver-kidney microsomal antibodies

initialism: LKM
synonym: LKM antibodies
https://doi.org/10.1351/goldbook.13392
Autoantibodies directed against cytochrome P450 and uridine diphosphate (UDP)-glucuronosyltransferase (UGT) antigens typically found in patients with immune-mediated hepatitis.
Note: These include LKM-1 antibodies (cytochrome P4502D6) in patients with autoimmune hepatitis type 2 (AIH-2) and autoimmunity associated with hepatitis C; LKM-2 (cytochrome P4502C9) in patients with drug-induced hepatitis caused by tienilic acid; and LKM-3 (UGT-1) in patients with chronic hepatitis D and AIH-2.
Source:
PAC, 2012, 84, 1113. (IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)) on page 1203 [Terms] [Paper]
Citation: 'liver-kidney microsomal antibodies' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.13392 RIS BibTex EndNote
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