13392 IUPAC Gold Book - liver-kidney microsomal antibodies 10.1351/goldbook.13392 13392 current initialism: LKM synonym: LKM antibodies 1 Autoantibodies directed against cytochrome P450 and uridine diphosphate (UDP)-glucuronosyltransferase (UGT) antigens typically found in patients with immune-mediated hepatitis. These include LKM-1 antibodies (cytochrome P4502D6) in patients with autoimmune hepatitis type 2 (AIH-2) and autoimmunity associated with hepatitis C; LKM-2 (cytochrome P4502C9) in patients with drug-induced hepatitis caused by tienilic acid; and LKM-3 (UGT-1) in patients with chronic hepatitis D and AIH-2. Autoantibodies https://goldbook.iupac.org//terms/view/12913 autoimmune https://goldbook.iupac.org//terms/view/12918 autoimmunity https://goldbook.iupac.org//terms/view/12925 PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1203 (https://doi.org/10.1351/PAC-REC-11-06-03) https://goldbook.iupac.org/terms/view/13392/html https://goldbook.iupac.org/terms/view/13392/json https://goldbook.iupac.org/terms/view/13392/plain Citation: 'liver-kidney microsomal antibodies' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13392 The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) for individual terms. If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org . The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using. 2026-04-17T21:33:08+00:00