preclinical candidate

initialism: PCC
synonym: safety assessment candidate
https://doi.org/10.1351/goldbook.12716
Optimised lead compound successfully passing key screening, selectivity, and physicochemical criteria sufficient to warrant further detailed pharmacological and pharmacokinetic evaluation in animal models.
Note: Critical studies usually include bioavailability, therapeutic efficacy in an appropriate disease model, and side-effect profiling.
Source:
PAC, 2013, 85, 1725. (Glossary of terms used in medicinal chemistry. Part II (IUPAC Recommendations 2013)) on page 1748 [Terms] [Paper]
Citation: 'preclinical candidate' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.12716 RIS BibTex EndNote
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