12716 IUPAC Gold Book - preclinical candidate 10.1351/goldbook.12716 12716 current initialism: PCC synonym: safety assessment candidate 1 Optimised lead compound successfully passing key screening, selectivity, and physicochemical criteria sufficient to warrant further detailed pharmacological and pharmacokinetic evaluation in animal models. Critical studies usually include bioavailability, therapeutic efficacy in an appropriate disease model, and side-effect profiling. lead https://goldbook.iupac.org//terms/view/12677 PAC, 2013, 85, 1725. 'Glossary of terms used in medicinal chemistry. Part II (IUPAC Recommendations 2013)' on page 1748 (https://doi.org/10.1351/PAC-REC-12-11-23) https://goldbook.iupac.org/terms/view/12716/html https://goldbook.iupac.org/terms/view/12716/json https://goldbook.iupac.org/terms/view/12716/plain Citation: 'preclinical candidate' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.12716 The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) for individual terms. If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org . The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using. 2026-04-21T08:40:10+00:00