ATP binding cassette protein

synonym: ABC protein
https://doi.org/10.1351/goldbook.12620
Large gene family of transporter proteins that bind ATP and use the energy to transport substrates (e.g., sugars, amino acids, metal ions, peptides, proteins, and a large number of hydrophobic compounds and metabolites) across lipid membranes.
Note: These proteins have an important role in limiting oral absorption and brain penetration of xenobiotics.
See also: efflux pump, P-glycoprotein
Source:
PAC, 2013, 85, 1725. (Glossary of terms used in medicinal chemistry. Part II (IUPAC Recommendations 2013)) on page 1727 [Terms] [Paper]
Citation: 'ATP binding cassette protein' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.12620 RIS BibTex EndNote
TextXMLJSON