Title: ATP binding cassette protein
Long Title: IUPAC Gold Book - ATP binding cassette protein
DOI: 10.1351/goldbook.12620
Status: current

Definition
Large gene family of transporter proteins that bind ATP and use the energy to transport substrates (e.g., sugars, amino acids, metal ions, peptides, proteins, and a large number of hydrophobic compounds and metabolites) across lipid membranes.

Note
These proteins have an important role in limiting oral absorption and brain penetration of xenobiotics.

Related Terms
- P-glycoprotein: https://goldbook.iupac.org//terms/view/12704
- efflux pump: https://goldbook.iupac.org//terms/view/12653

Source
- PAC, 2013, 85, 1725. 'Glossary of terms used in medicinal chemistry. Part II (IUPAC Recommendations 2013)' on page 1727 (https://doi.org/10.1351/PAC-REC-12-11-23)

Other Outputs
- html: https://goldbook.iupac.org/terms/view/12620/html
- json: https://goldbook.iupac.org/terms/view/12620/json
- xml: https://goldbook.iupac.org/terms/view/12620/xml

Citation: Citation: 'ATP binding cassette protein' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.12620
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Disclaimer: The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.
Accessed: 2026-07-14T00:25:00+00:00