analogue-based drug discovery

synonym: analog-based drug discovery
https://doi.org/10.1351/goldbook.12619
Strategy for drug discovery and/or optimization in which structural modification of an existing drug provides a new drug with improved chemical and/or biological properties.
Note: Within the context of analogue-based drug discovery, three categories of drug analogues are recognized: Compounds possessing structural, chemical, and pharmacological similarities, termed "direct analogues" and sometimes referred to as "me-too" drugs; compounds possessing structural and often chemical but not pharmacological similarities, termed "structural analogues"; and structurally different compounds displaying similar pharmacological properties, termed "pharmacological analogues".
See also: ligand-based drug design
Source:
PAC, 2013, 85, 1725. (Glossary of terms used in medicinal chemistry. Part II (IUPAC Recommendations 2013)) on page 1727 [Terms] [Paper]
Citation: 'analogue-based drug discovery' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.12619 RIS BibTex EndNote
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