{"term":{"id":"12619","title":"analogue-based drug discovery","longtitle":"IUPAC Gold Book - analogue-based drug discovery","doi":"10.1351\/goldbook.12619","code":"12619","status":"current","synonym":"<em>synonym<\/em>: analog-based drug discovery","definitions":[{"id":1,"text":"Strategy for drug discovery and\/or optimization in which structural modification of an existing drug provides a new drug with improved chemical and\/or biological properties.","notes":{"1":"Within the context of analogue-based drug discovery, three categories of drug analogues are recognized: Compounds possessing structural, chemical, and pharmacological similarities, termed \"direct analogues\" and sometimes referred to as \"me-too\" drugs; compounds possessing structural and often chemical but not pharmacological similarities, termed \"structural analogues\"; and structurally different compounds displaying similar pharmacological properties, termed \"pharmacological analogues\"."},"links":[{"term":"\"me-too\" drugs","url":"https:\/\/goldbook.iupac.org\/\/terms\/view\/12681"},{"term":"ligand-based drug design","url":"https:\/\/goldbook.iupac.org\/\/terms\/view\/12679"}],"sources":["PAC, 2013, 85, 1725. 'Glossary of terms used in medicinal chemistry. Part II (IUPAC Recommendations 2013)' on page 1727 (https:\/\/doi.org\/10.1351\/PAC-REC-12-11-23)"]}],"altoutputs":{"html":"https:\/\/goldbook.iupac.org\/terms\/view\/12619\/html","xml":"https:\/\/goldbook.iupac.org\/terms\/view\/12619\/xml","plain":"https:\/\/goldbook.iupac.org\/terms\/view\/12619\/plain"},"citation":"Citation: 'analogue-based drug discovery' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351\/goldbook.12619","license":"The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/) for individual terms.","collection":"If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org .","disclaimer":"The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.","accessed":"2026-05-09T12:50:22+00:00"}}