lipophilic ligand efficiency

initialism: LLE
https://doi.org/10.1351/goldbook.11465
A measure of the efficiency of ligand binding that is corrected for binding driven by lipophilicity.
Note: It is calculated as; \[LLE = \pu{p}K_{i} - \log P\] values of seven or greater are considered characteristic of a good clinical candidate.
Source:
PAC, 2016, 88, 239. (Glossary of terms used in computational drug design, part II (IUPAC Recommendations 2015)) on page 249 [Terms] [Paper]
Citation: 'lipophilic ligand efficiency' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.11465 RIS BibTex EndNote
Div. VIITextXMLJSON