A measure of the efficiency of ligand binding that is corrected for binding driven by lipophilicity.
Note: It is calculated as; \[LLE = \pu{p}K_{i} - \log P\] values of seven or greater are considered characteristic of a good clinical candidate.
Source:
PAC, 2016, 88, 239. 'Glossary of terms used in computational drug design, part II (IUPAC Recommendations 2015)' on page 249 (https://doi.org/10.1515/pac-2012-1204)