Title: lipophilic ligand efficiency
Long Title: IUPAC Gold Book - lipophilic ligand efficiency
DOI: 10.1351/goldbook.11465
Status: current

Definition
A measure of the efficiency of ligand binding that is corrected for binding driven by lipophilicity.

Note
It is calculated as; \[LLE = \pu{p}K_{i} - \log P\] values of seven or greater are considered characteristic of a good clinical candidate.

Source
- PAC, 2016, 88, 239. 'Glossary of terms used in computational drug design, part II (IUPAC Recommendations 2015)' on page 249 (https://doi.org/10.1515/pac-2012-1204)

Other Outputs
- html: https://goldbook.iupac.org/terms/view/11465/html
- json: https://goldbook.iupac.org/terms/view/11465/json
- xml: https://goldbook.iupac.org/terms/view/11465/xml

Citation: Citation: 'lipophilic ligand efficiency' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.11465
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Accessed: 2026-05-18T07:15:00+00:00