malignant

antonym: benign
https://doi.org/10.1351/goldbook.10915
  1. Occurring in a severe form, tending to become progressively worse, resistant to treatment, and likely to result in death.
  2. In cancer, cells showing both uncontrolled growth and a tendency to invade and destroy other tissues.
Source:
PAC, 2016, 88, 713. (Glossary of terms used in developmental and reproductive toxicology (IUPAC Recommendations 2016)) on page 775 [Terms] [Paper]