- Occurring in a severe form, tending to become progressively worse, resistant to treatment, and likely to result in death.
- In cancer, cells showing both uncontrolled growth and a tendency to invade and destroy other tissues.
Source:
PAC, 2016, 88, 713. 'Glossary of terms used in developmental and reproductive toxicology (IUPAC Recommendations 2016)' on page 775 (https://doi.org/10.1515/pac-2015-1202)