https://doi.org/10.1351/goldbook.10539
Condition caused by the continued ingestion of low but toxic levels of estrogens.
Notes:
- The most important occurrence is in farm animals pastured on plants containing phytoestrogens. The signs are those related to endometrial hyperplasia and vaginal tumefaction (swelling and puffiness), including long-term infertility and rectalprolapse, especially in pigs; uterine prolapse, especially in ewes; and feminization of males that have undergone castration.
- Dogs are particularly susceptible to the myelotoxic effects of estrogens and high dose or prolonged administration causes severe bone marrow depression with thrombocytopenia, followed by leukopenia and anemia.