clover disease

synonym: estrogenism
https://doi.org/10.1351/goldbook.10539

Condition caused by the continued ingestion of low but toxic levels of estrogens.

Notes:
  1. The most important occurrence is in farm animals pastured on plants containing phytoestrogens. The signs are those related to endometrial hyperplasia and vaginal tumefaction (swelling and puffiness), including long-term infertility and rectalprolapse, especially in pigs; uterine prolapse, especially in ewes; and feminization of males that have undergone castration.
  2. Dogs are particularly susceptible to the myelotoxic effects of estrogens and high dose or prolonged administration causes severe bone marrow depression with thrombocytopenia, followed by leukopenia and anemia.
Source:
PAC, 2016, 88, 713. 'Glossary of terms used in developmental and reproductive toxicology (IUPAC Recommendations 2016)' on page 737 (https://doi.org/10.1515/pac-2015-1202)