high-speed counter-current chromatography

initialism: HSCCC
https://doi.org/10.1351/goldbook.09944

Counter-current chromatography system using a multilayer coil separation column, which undergoes a type-J synchronous planetary motion (see figure).

Note: The method covers analytical (microgram) to preparative (\(\pu{10 g}\)) scale separations usually in a few hours at a high partition efficiency up to a few thousand theoretical plates (see number of theoretical plates).

Type-J planetary motion of a multilayer coil separation column. The column holder rotates about its own axis and revolves around the centrifuge axis at the same angular velocity (ω) in the same direction. This planetary motion prevents twisting of the bundle of flow tubes, allowing continuous elution through a rotating column without risk of leakage and contamination.

Source:
PAC, 2017, 90, 181. (Terminology of separation methods (IUPAC Recommendations 2017)) on page 203 [Terms] [Paper]