hydrophobic-interaction chromatography

initialism: HIC
https://doi.org/10.1351/goldbook.09891
Chromatography in which molecules are separated by interactions between their hydrophobic moieties and hydrophobic sites on the surface of the stationary phase.
Note: High salt concentrations are used in the mobile phase and separations are effected by changing the salt concentration. Gradients are run by decreasing the salt concentration over time.
Source:
PAC, 2017, 90, 181. (Terminology of separation methods (IUPAC Recommendations 2017)) on page 187 [Terms] [Paper]
Citation: 'hydrophobic-interaction chromatography' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.09891 RIS BibTex EndNote
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