Title: synergism
Long Title: IUPAC Gold Book - synergism
DOI: 10.1351/goldbook.S06229
Status: current

Definition
Pharmacological or toxicological interaction in which the combined biological effect of two or more substances is greater than expected on the basis of the simple summation of the toxicity of each of the individual substances.

Related Term
- toxicity: https://goldbook.iupac.org//terms/view/T06414

Source
- PAC, 1993, 65, 2003. 'Glossary for chemists of terms used in toxicology (IUPAC Recommendations 1993)' on page 2103 (https://doi.org/10.1351/pac199365092003)

Other Outputs
- html: https://goldbook.iupac.org/terms/view/S06229/html
- json: https://goldbook.iupac.org/terms/view/S06229/json
- xml: https://goldbook.iupac.org/terms/view/S06229/xml

Citation: Citation: 'synergism' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.S06229
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Accessed: 2026-06-07T09:29:02+00:00