Title: mutation rate Long Title: IUPAC Gold Book - mutation rate DOI: 10.1351/goldbook.M04075 Status: current Definition The frequency (\(\rm{h}^{-1}\)) with which a mutation occurs within a organism or gene. In general, rates of spontaneous mutation vary between one in \(10^{4}\) and one in \(10^{8}\) per gene per generation, and can be considerably increased by mutagens. Related Terms - gene: https://goldbook.iupac.org//terms/view/G02604 - mutation: https://goldbook.iupac.org//terms/view/M04074 Source - PAC, 1992, 64, 143. 'Glossary for chemists of terms used in biotechnology (IUPAC Recommendations 1992)' on page 161 (https://doi.org/10.1351/pac199264010143) Other Outputs - html: https://goldbook.iupac.org/terms/view/M04075/html - json: https://goldbook.iupac.org/terms/view/M04075/json - xml: https://goldbook.iupac.org/terms/view/M04075/xml Citation: Citation: 'mutation rate' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.M04075 License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) for individual terms. Collection: If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org . Disclaimer: The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using. Accessed: 2026-05-01T03:57:38+00:00