High @DT07361@ used in @CT06817@ testing that is expected on the basis of an adequate subchronic study to produce limited @T06414@ when administered for the duration of the test period. It should not induce: (a) overt @T06414@, for example appreciable death of cells or organ dysfunction, or (b) toxic manifestations that are predicted materially to reduce the life span of the animals except as the result of neoplastic development or (c) 10% or greater retardation of body @W06668@ gain as compared with control animals. In some studies, @T06414@ that could interfere with a carcinogenic effect is specifically excluded from consideration.